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Enhertu Cycle #15 #16 and Update - 12/6/25

  • Writer: Stacy Caldwell
    Stacy Caldwell
  • 14 minutes ago
  • 5 min read

It’s been about a month, so I wanted to share another update.  Last time I shared that I am currently no evidence of active disease and have been enjoying the bliss that comes with news like this.  I don’t take this win for granted, because I know what the other side of this coin feels like.   


Lately life has been good.  People often ask me how I am feeling and doing, and I reply that I am doing well and feeling good.  Lately I’ve had a ton of energy and haven’t been feeling many side effects from the Enhertu treatment.  Usually for a week after treatment I am feeling fatigued, but this last round I seemed to not feel fatigued as much.  The day after my treatment I traveled back to New Mexico for Thanksgiving and had enough energy to get through the travel days.  I even went to the gym to lift weights and go on my usual three mile run a few days after treatment.  The way I have been feeling has brought so much peace into my life as of late, and just so so very thankful.  My prayers are being answered!


I’ve now completed treatment #16 for Enhertu.  At the end of December, I will have completed a whole year on this treatment!  Words can’t even describe how grateful I feel to be on a treatment that is working and giving me the best quality of life.  If we can turn this into something that is incurable and terminal to one that is chronic, I would be on cloud nine forever.  I continue to have hope and faith that everything will work out just fine.

In addition to treatment, I had my brain MRI back in November and happy to report that everything with that came back normal!  I continue to be so happy that everything looks fine with my brain!  We will keep doing Brain MRIs every few months along with the PET scans. 


I mentioned last time that I am getting the cancer antigen 15-3 blood test every three weeks now with my infusion.  It’s a blessing and a curse because on one hand, I want to see if the number goes up or down which can tell me before my scans whether or not the cancer has spread, but on the other hand, I now get anxiety every three weeks to see what this number says.  It is so nerve-wracking to have information like this at your fingertips more often than scans every three months.  But I am trusting the process.  Thankfully my 15th infusion showed a number of 33, which is just above normal range but nothing to worry about and then for my 16th infusion, that number remained stable at 33 again.  This brought me so much relief that nothing is changing.  Now, I wait to see what the number shows when I go in on the 15th of December for my 17th infusion.


Speaking of the 15th of Dec, me and this other stage 4 thriver signed up to play in a cornhole tournament that evening! So excited to see how we do and blessed to have new friends to spend time with.  I can say that breast cancer and what it’s brought to my life including new friends has been such a blessing in all of this. 


As I mentioned, I went back to NM for Thanksgiving which was a really nice time with family and friends.  I got to see my aunts and uncles on my dad’s side and celebrated my dad’s birthday when I was down there.  I unfortunately didn’t get to see my sister the entire time though since she was sick with Covid.  Hoping I will see her around Christmas time.

Since being back home I have been getting back into my little routine.  Loving the little life I have built myself with Obie.  We ended up getting a good amount of snow in Minnesota so everything looks so beautiful outside!  I recently bought a new Christmas tree and enjoying the coziness inside, drinking tea from my new xmas mug I bought, to doing jigsaw puzzles, listening to country music and watching some good tv shows, all cuddled up with Obie.  I am also making good progress on my book, which I have written about 5 chapters on so far, and have a pretty good outline for how it all will come together, thanks to this memoir class I am taking. 


In other news, prior to Thanksgiving, I went on a date!  I posted some details on my social media about how the date went, but let’s just say we are not talking anymore.  We ended up playing pickleball, which he showed up in Whitney Houston t-shirt 45 minutes late to, and then as we were talking and I told him about my diagnosis and how I will be in treatment for the rest of my life, his reply to all that was, “Good Luck.”  I just don’t think he had the emotional intelligence to have a mature conversation about anything.  But his loss and now I have a fun story from the date.  I am currently on a couple dating sites, but nothing exciting happening at the moment.  I am at peace with my life as it is and if I meet someone to share my life with that is amazing, then great, but not going to force anything. 

In other fun news, I am going to be on a podcast called Pink Power Hour hosted by my friends Jenna and Amy, who were also in the documentary.  We are recording on Tuesday and then a few weeks later the episode will be featured on the podcast.  I will share more next time, but you can catch the podcast wherever you get your podcasts 😊


In addition, this coming week I will be heading back to Mayo Clinic for a meeting with the radiation oncologist to see how I am doing on the clinical trial.  I just keep thinking how everything fell into place with the clinical trial.  I was the perfect candidate at the right place, right time.  If I didn’t do the clinical trial, not sure where I would be at this point. 

But anyways, lately I’ve been soaking in all the good news happening in my life and relishing in the fact that I am feeling good mentally and physically.  I am feeling joy again, and I am so grateful for that.  I know not everyone in my situation feels the same way, as I see on social media from other stage 4 women I follow.  A few are having horrible side effects from their treatments, even on Enhertu, where they can’t even get out of bed, or have trouble going up the stairs.  I feel for them so much and just want to take away the pain from all of us stage 4 women! 


To wrap up this update, I just want to say I appreciate everyone in my life near and far.  Those that follow along my journey and read my updates, to those that follow me on social media, to my family and friends, I am reminded over and over again how there is so much good in this world, in my life, and the people around me is what matters most. 


My next scan is on Jan 5th so I will be sure to share another update then – good news hopefully!


Hope everyone had a great Thanksgiving and has wonderful Christmas coming up!


 Love, Stacy


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